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KMID : 0352120010170020187
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Journal of Kyung Hee University
2001 Volume.17 No. 2 p.187 ~ p.198
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The Regulation Effects of Sibak-tang on Cytokines at the Supernatant of PHA-P Stimulated Peripheral Blood Mononuclear Cell in Patients with Minimal Change Nephrotic Syndrome
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두호경(杜鎬京)/Ho Kyung Doo
안영민(安永敏)/안세영(安世永)/Young Min Ahn/Se Young Ahn
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Abstract
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The purpose of this research is to investigate the synergistic effect of herb me
dicines with hydrocortisone and the regulation effect on immune system of Sibak-
tang at the supernatant of PHA-P stimulated PBMC in the patients with minimal ch
ange nephrotic syndrome(MCNS). From the measurement of the concentration rate of
IL-4, sCD23 and IL-13, the experiment yielded the following results :
The Sibak-tang group, though not statistically significant, was inclined to suppress IL-4 level in MCNS patients. It shows stronger suppression in sCD23 and IL-13 levels than these of control group in MCNS group.
As for the synergistic effect, the group of hydrocortisone with Sibak-tang produced more suppressive effect to IL-13 level in MCNS group than that of hydrocortisone-only group That also tend to suppress sCD23 and IL-4 levels, though no
statistical
significance can given. As to the suppressive effect of IL-13 level, the group of Sibakt-ang with hydrocortisone shows an increase of 24.01%
From the above results, a combinative treatment (herb medicines with hydrocortisone) can be an alternative method to substitute for the steroid therapy. It can be more effective therapy than the steroid-only therapy because it is expected to
reduce
side
effects and it shows more special effect to suppress IL-13 level. Based on the present results, further investigation concerning the serum IgE elevation are needed.
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KEYWORD
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